Artisanal and small-scale mining (ASM) plays a key social role for Chile and the territories in which it is developed. However, unlike their large mining peers, they normally suffer from situations of social vulnerability, lack of financing and maintain precarious formalization processes. They are also overrepresented in fatal accidents, having difficulties in meeting standards in both the areas of Occupational Health and Safety (OHS) and environmental standards. These difficulties generate an environment where ASM does not reach its full potential for the development of the country, its territories and to provide decent conditions for its workers. We propose a systemic program based on evidence and research, integrating local context, technological modernization, best productive, SSO and socio-environmental practices, seeking the sustainability and prosperity of operations.